The residence was designed by Bugbee & Sons, Architects, San Francisco. The Chronicle noted that, "the basement is to be of brick, the two stories above it of wood, with handsome ornaments. The lot is 412 1/2 x 275 feet in size. The house will be about 125 feet square on the ground, and the largest private residence in the State. The main front on California street will be in the composite style of architecture and quiet elaborate, having flat windows and a porch 50 feet long by 14 feet broad, supported by sixteen Corinthian columns. The steps and buttresses of the porch are to be of marble. The house will have a hip roof, giving a high attic, surmounted by an iron cresting and ornamental chimneys. The roof will be covered with copper. The other three sides of the house will have the same general dimensions and appearance, but will be relieved by bow windows. The carriage porch will be on the Powell-street front. The rear front will be relieved by a balcony and conservatory."
The Stanford Mansion was destroyed in the fire following the earthquake of April 18, 1906. The Stanford Court Apartments (later hotel) were erected on the site in 1912.